High white matter hyperintensity burden in strategic white matter tracts relates to worse global cognitive performance in community-dwelling individuals
Publication in refereed journal

替代計量分析
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其它資訊
摘要Background
White matter hyperintensities (WMH) are associated with cognitive impairment. The impact of WMH on cognitive domains (e.g. processing speed, executive functioning) depends on location. We determined whether the relevance of WMH location also applies to global cognitive functioning by testing if WMH in strategic white matter tracts are associated with global cognitive functioning independent of total WMH burden.

Methods
We included 830 community-dwelling individuals. WMH volume within two a priori specified strategic white matter tracts (forceps minor and anterior thalamic radiation) were entered in a linear regression model with the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) as outcome variables and corrected for total WMH volume and other MRI markers for vascular injury and neurodegenerations (i.e. brain parenchymal fraction, and the presence of lacunes and microbleeds).

Results
WMH in the forceps minor and left anterior thalamic radiation inversely correlated with MoCA, and WMH in the forceps minor inversely correlated with MMSE, independent of total WMH volume and other MRI markers.

Conclusion
The impact of WMH on global cognitive functioning depends on location. Whether this reflects accumulated impairment in isolated cognitive domains or disruption of a network that is crucially involved in global cognitive performance remains to be determined.
出版社接受日期10.04.2020
著者J Matthijs Biesbroek, Bonnie Y K Lam, Lei Zhao, Yumi Tang, Zhaolu Wang, Jill Abrigo, Winnie W C Chu, Adrian Wong, Lin Shi, Hugo J Kuijf, Geert Jan Biessels, Vincent C T Mok
期刊名稱Journal of the Neurological Sciences
出版年份2020
月份7
日期15
卷號414
文章號碼116835
國際標準期刊號0022-510X
電子國際標準期刊號1878-5883
語言美式英語

上次更新時間 2020-02-12 於 23:50