High white matter hyperintensity burden in strategic white matter tracts relates to worse global cognitive performance in community-dwelling individuals
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AbstractBackground
White matter hyperintensities (WMH) are associated with cognitive impairment. The impact of WMH on cognitive domains (e.g. processing speed, executive functioning) depends on location. We determined whether the relevance of WMH location also applies to global cognitive functioning by testing if WMH in strategic white matter tracts are associated with global cognitive functioning independent of total WMH burden.

Methods
We included 830 community-dwelling individuals. WMH volume within two a priori specified strategic white matter tracts (forceps minor and anterior thalamic radiation) were entered in a linear regression model with the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) as outcome variables and corrected for total WMH volume and other MRI markers for vascular injury and neurodegenerations (i.e. brain parenchymal fraction, and the presence of lacunes and microbleeds).

Results
WMH in the forceps minor and left anterior thalamic radiation inversely correlated with MoCA, and WMH in the forceps minor inversely correlated with MMSE, independent of total WMH volume and other MRI markers.

Conclusion
The impact of WMH on global cognitive functioning depends on location. Whether this reflects accumulated impairment in isolated cognitive domains or disruption of a network that is crucially involved in global cognitive performance remains to be determined.
Acceptance Date10/04/2020
All Author(s) ListJ Matthijs Biesbroek, Bonnie Y K Lam, Lei Zhao, Yumi Tang, Zhaolu Wang, Jill Abrigo, Winnie W C Chu, Adrian Wong, Lin Shi, Hugo J Kuijf, Geert Jan Biessels, Vincent C T Mok
Journal nameJournal of the Neurological Sciences
Year2020
Month7
Day15
Volume Number414
Article number116835
ISSN0022-510X
eISSN1878-5883
LanguagesEnglish-United States

Last updated on 2020-19-10 at 01:24