Gender differences in mortality and quality of life after septic shock: A post-hoc analysis of the ARISE study
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AbstractPurpose
To assess the impact of gender and pre-menopausal state on short- and long-term outcomes in patients with septic shock.

Material and methods
Cohort study of the Australasian Resuscitation in Sepsis Evaluation (ARISE) trial, an international randomized controlled trial comparing early goal-directed therapy (EGDT) to usual care in patients with early septic shock, conducted between October 2008 and April 2014. The primary exposure in this analysis was legal gender and the secondary exposure was pre-menopausal state defined by chronological age (≤ 50 years).

Results
641 (40.3%) of all 1591 ARISE trial participants in the intention-to-treat population were females and overall, 337 (21.2%) (146 females) patients were 50  years of age or younger. After risk-adjustment, we could not identify any survival benefit for female patients at day 90 in the younger (≤50 years) (adjusted Odds Ratio (aOR): 0.91 (0.46–1.89), p = .85) nor in the older (>50 years) age-group (aOR: 1.10 (0.81–1.49), p = .56). Similarly, there was no gender-difference in ICU, hospital, 1-year mortality nor quality of life measures.

Conclusions
This post-hoc analysis of a large multi-center trial in early septic shock has shown no short- or long-term survival effect for women overall as well as in the pre-menopausal age-group.
All Author(s) ListLuethi N, Bailey M, Higgins A, Howe B, Peake S, Delaney A, Bellomo R, ARISE investigators
Journal nameJournal of Critical Care
Year2020
Month2
Volume Number55
PublisherW.B. Saunders; Elsevier
Pages177 - 183
ISSN0883-9441
eISSN1557-8615
LanguagesEnglish-United Kingdom
KeywordsIntensive care, Sepsis, Septic shock, Outcomes, Sex, Gender difference, Age, Pre-menopausal state
Web of Science Subject CategoriesCritical Care Medicine;General & Internal Medicine

Last updated on 2020-23-10 at 00:38