Gastric cancer: genome damaged by bugs
Publication in refereed journal

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其它資訊
摘要Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide. The role of the microorganisms in gastric tumorigenesis attracts much attention in recent years. These microorganisms include bacteria, virus, and fungi. Among them, Helicobacter pylori (H. pylori) infection is by far the most important risk factor for GC development, with special reference to the early-onset cases. H. pylori targets multiple cellular components by utilizing various virulence factors to modulate the host proliferation, apoptosis, migration, and inflammatory response. Epstein-Barr virus (EBV) serves as another major risk factor in gastric carcinogenesis. The virus protein, EBER noncoding RNA, and EBV miRNAs contribute to the tumorigenesis by modulating host genome methylation and gene expression. In this review, we summarized the related reports about the colonized microorganism in the stomach and discussed their specific roles in gastric tumorigenesis. Meanwhile, we highlighted the therapeutic significance of eradicating the microorganisms in GC treatment.
著者Yanan ZHAO , Jinglin ZHANG, Alfred S L CHENG, Jun YU, Ka Fai TO, Wei KANG
期刊名稱Oncogene
出版年份2020
月份4
卷號39
期次17
出版社Nature Publishing Group
頁次3427 - 3442
國際標準期刊號0950-9232
語言英式英語

上次更新時間 2020-23-11 於 23:44