Toward personalization of asthma treatment according to trigger factors
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AbstractAsthma is a severe and chronic disabling disease affecting more than 300 million people worldwide. Although in the past few drugs for the treatment of asthma were available, new treatment options are currently emerging, which appear to be highly effective in certain subgroups of patients. Accordingly, there is a need for biomarkers that allow selection of patients for refined and personalized treatment strategies. Recently, serological chip tests based on microarrayed allergen molecules and peptides derived from the most common rhinovirus strains have been developed, which may discriminate 2 of the most common forms of asthma, that is, allergen- and virus-triggered asthma. In this perspective, we argue that classification of patients with asthma according to these common trigger factors may open new possibilities for personalized management of asthma.
Acceptance Date07/02/2020
All Author(s) ListKatarzyna Niespondziana, Kristina Borochova, Petra Pazderova, Thomas Schlederer, Natalia Astafyeva, Tatiana Baranovskaya, Mohamed-Ridha Barbouche, Evgeny Beltyukov, Angelika Berger, Elena Borzova, Jean Bousquet, Roxana S. Bumbacea, Snezhana Bychkovskaya, Luis Caraballo, Kian Fan Chung, Adnan Custovic, Guillermo Docena, Thomas Eiwegger, Irina Evsegneeva, Alexander Emelyanov, Peter Errhalt, Rustem Fassakhov, Rezeda Fayzullina, Elena Fedenko, Daria Fomina, Zhongshan Gao, Pedro Giavina-Bianchi, Maia Gotua, Susanne Greber-Platzer, Gunilla Hedlin, Natalia llina, Zhanat Ispayeva, Marco Idzko, Sebastian L. Johnston, Omer Kalayci, Alexander Karaulov, Antonina Karsonova, Musa Khaitov, Elena Kovzel, Marek L. Kowalski, Dmitry Kudlay, Michael Levin, Svetlana Makarova, Paolo Maria Matricardi, Kari C. Nadeau, Leyla Namazova-Baranov, Olga Naumova, Oleksandr Nazarenko, Paul M. O'Byrne, Faith Osier, Alexander N. Pampura, Carmen Panaitescu, Nikolaos G. Papadopoulos, Hae-Sim Park, Ruby Pawankar, Wolfgang Pohl, Harald Renz, Ksenja Riabova, Vanitha Sampath, Bulent E. Sekerel, Elopy Sibanda, Valerie Siroux, Ludmila P. Sizyakina, Jin-Lyn Sun, Zsolt Szepfalusi, Tetiana Umanets, Hugo P.S. Van Bever, Marianne van Hage, Margarita Vasileva, Erika von Mutius, Jiu-Yao Wang, Gary WK Wong, Sergii Zaikov, Mihaela Zidarn, Rudolf Valenta
Journal nameJournal of Allergy and Clinical Immunology
Year2020
Month6
Volume Number145
Issue Number6
PublisherElsevier
Pages1529 - 1534
ISSN0091-6749
eISSN1097-6825
LanguagesEnglish-United Kingdom
KeywordsAsthma, allergy, wheeze, rhinovirus, allergen, microarray

Last updated on 2021-14-09 at 23:58