Time course of blood oxygen saturation responding to short-term fine particulate matter among elderly healthy subjects and patients with chronic obstructive pulmonary disease
Publication in refereed journal


摘要Patients with chronic obstructive pulmonary disease (COPD) often experience deteriorating gaseous exchange which in turn may result in declines in blood oxygen saturation (SpO(2)). Increasing evidence has also shown that elevated levels of fine particulate matter (PM2.5) may contribute to COPD pathogenesis. However, the acute effects of PM2.5 on SpO(2) among COPD patients remain unclear, especially for its time course. Therefore, we conducted this panel study with 3-day real-time monitoring for personal PM2.5 exposure and concurrent SpO(2) of 39 participants (20 COPD patients, 19 healthy participants), aged 60 to 90 years, in Hong Kong to explore the acute effects of personal PM2.5 exposure on SpO(2) (within minutes to hours). We applied a linear mixed effect model to examine the associations between personal PM2.5 and SpO(2), while adjusting for temporal trend, personal characteristics, weather conditions, and co-exposure to gaseous pollutants (ambient ozone, nitrogen dioxides, carbon monoxide, and atmospheric pressure). We found that short-term exposure to PM2.5 might result in acute declines of SpO(2) within minutes, and the effects would last for several hours. An interquartile range increase of personal PM2.5 exposure (17.2 mu g/m(3)) was associated with-0.19% (95% CI:-0.26% to-0.12%) changes of concurrent SpO(2) for all participants. The most significant decline was observed at lag0-3 h, and then became insignificant at lag0-12 h. At lag0-1 h, estimated mean changes of SpO(2) were -0.40% (95% CI: -0.55% to -0.24%) for COPD patients and -0.09% (95% CI: -0.23% to 0.06%) for healthy participants. Compared with healthy participants, the effects of PM2.5 exposure on SpO(2) for COPD patients were slightly stronger and more acute. Reducing PM2.5 concentrations might be a useful approach to improve health status and reduce exacerbations for COPD patients.
著者Xia X, Qiu H, Kwok T, Ko FWS, Man CL, Ho KF
期刊名稱Science of the Total Environment
關鍵詞Air pollution, COPD, Oxygen saturation, Real-time monitoring, Time course
Web of Science 學科類別Environmental Sciences;Environmental Sciences & Ecology

上次更新時間 2020-26-10 於 00:11