Assessment and staging of nasopharyngeal carcinoma
Chapter in an edited book (author)

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AbstractIn nasopharyngeal carcinoma (NPC) endemic areas, assessment and staging of NPC contribute to early diagnosis, timely treatment planning, and ultimately better outcomes. Routine assessment procedures consist of: history taking; physical examination of the head, neck, and cranial nerve; laboratory tests including blood tests and serological testing; nasopharyngoscopy with biopsy; and imaging. Imaging may include computed tomography scan (CT) or magnetic resonance imaging (MRI) of the nasopharynx, base of skull, and neck. Imaging of the whole body may also be performed via bone scans or positron emission tomography CT/MRI. Becuase Epstein–Barr virus (EBV) is strongly associated with the development of NPC, detection of EBV antibodies has been effective for early detection of NPC. Recent studies have focused on Epstein–Barr virus DNA load in plasma for screening, early diagnosis, and prognosis of NPC. On the other hand, staging is the process of determining the size and region of the tumor and the spread of the cancer. Staging helps to determine appropriate treatment and predict the outcome of the disease. The tumor, node, and metastasis system promoted by the eighth edition (2017) of the Union for International Cancer Control and American Joint Committee on Cancer is the most recent and most common clinical standard of NPC staging for appropriate diagnosis, treatment, and prognosis. This chapter summarizes the day to day execution and latest developments in NPC assessment and staging, which are most relevant to clinicians who might see these patients either occasionally or on a regular basis.
All Author(s) ListKarman KY Leung, Michael CF Tong
All Editor(s) ListBaharudin Abdullah, Anusha Balasubramanian, Norhafiza Mat Lazim
Book titleAn Evidence-Based Approach to the Management of Nasopharyngeal Cancer: From Basic Science to Clinical Presentation and Treatment
PublisherAcademic Press
Pages111 - 139
LanguagesEnglish-United Kingdom

Last updated on 2021-20-09 at 23:37