Structural Biology and Electron Microscopy of the Autophagy Molecular Machinery
Publication in refereed journal


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其它資訊
摘要Autophagy is a highly regulated bulk degradation process that plays a key role in the maintenance of cellular homeostasis. During autophagy, a double membrane-bound compartment termed the autophagosome is formed through de novo nucleation and assembly of membrane sources to engulf unwanted cytoplasmic components and targets them to the lysosome or vacuole for degradation. Central to this process are the autophagy-related (ATG) proteins, which play a critical role in plant fitness, immunity, and environmental stress response. Over the past few years, cryo-electron microscopy (cryo-EM) and single-particle analysis has matured into a powerful and versatile technique for the structural determination of protein complexes at high resolution and has contributed greatly to our current understanding of the molecular mechanisms underlying autophagosome biogenesis. Here we describe the plant-specific ATG proteins and summarize recent structural and mechanistic studies on the protein machinery involved in autophagy initiation with an emphasis on those by single-particle analysis.
出版社接受日期10.12.2019
著者Louis Tung Faat Lai, Hao Ye, Wenxin Zhang, Liwen Jiang, Wilson Chun Yu Lau
期刊名稱Cells
出版年份2019
月份12
卷號8
期次12
出版社MDPI
文章號碼1627
國際標準期刊號2073-4409
語言美式英語

上次更新時間 2021-13-01 於 23:39