MicroRNAs in atopic dermatitis: A systematic review
Publication in refereed journal


引用次數
Scopus ( 27/11/2020)
替代計量分析
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其它資訊
摘要Atopic dermatitis (AD) is a chronic and recurrent inflammatory skin disease, affecting up to 10% to 20% of children and 3% of adults. Although allergen sensitization, skin barrier abnormalities and type 2 immune responses are involved, the exact molecular pathogenesis of AD remains unclear. MicroRNAs (miRNAs) are short (19-25 nucleotides) single-stranded RNA molecules that regulate gene expression at post-transcriptional level and are implicated in the pathogenesis of many inflammatory and immunological skin disorders. This systematic review sought to summarize our current understanding regarding the role of miRNAs in AD development. We searched articles indexed in PubMed (MEDLINE) and Web of Science databases using Medical Subject Heading (MeSH) or Title/Abstract words ('microRNA/miRNA' and 'atopic dermatitis/eczema') from inception through January 2020. Observational studies revealed dysregulation of miRNAs, including miR-143, miR-146a, miR-151a, miR-155 and miR-223, in AD patients. Experimental studies confirmed their functions in regulating keratinocyte proliferation/apoptosis, cytokine signalling and nuclear factor-κB-dependent inflammatory responses, together with T helper 17 and regulatory T cell activities. Altogether, this systematic review brings together contemporary findings on how deregulation of miRNAs contributes to AD.
著者Yu X, Wang M, Li L, Zhang L, Chan MTV, Wu WKK
期刊名稱Journal of Cellular and Molecular Medicine
出版年份2020
月份6
卷號24
期次11
出版社Wiley
頁次5966 - 5972
國際標準期刊號1582-1838
電子國際標準期刊號1582-4934
語言英式英語

上次更新時間 2020-27-11 於 23:45