Emerging roles of non-coding RNAs in scoliosis
Publication in refereed journal


引用次數
Scopus ( 21/11/2020)
替代計量分析
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其它資訊
摘要Scoliosis, a complex three-dimensional deformity of the spine with the Cobb angle (a measure of the spinal lateral curvature) >10 degree, encompasses a spectrum of pathologies, including congenital, idiopathic, syndromic and neuromuscular aetiologies. The pathogenesis is multifactorial involving both environmental and genetic factors but the exact cellular and molecular mechanisms of disease development remain largely unknown. Emerging evidence showed that non-coding RNAs (ncRNAs), namely microRNAs, long ncRNAs and circular RNAs, are deregulated in many orthopaedic diseases, including scoliosis. Importantly, these deregulated ncRNAs functionally participate in the initiation and progression of scoliosis. Here, we review recent progress in ncRNA research on scoliosis.
著者Li Z, Li X, Shen J, Zhang L, Chan MTV, Wu WKK
期刊名稱Cell Proliferation
出版年份2020
月份2
卷號53
期次2
出版社Wiley
文章號碼e12736
國際標準期刊號0960-7722
電子國際標準期刊號1365-2184
語言英式英語

上次更新時間 2020-22-11 於 00:02