Emerging roles of non-coding RNAs in scoliosis
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AbstractScoliosis, a complex three-dimensional deformity of the spine with the Cobb angle (a measure of the spinal lateral curvature) >10 degree, encompasses a spectrum of pathologies, including congenital, idiopathic, syndromic and neuromuscular aetiologies. The pathogenesis is multifactorial involving both environmental and genetic factors but the exact cellular and molecular mechanisms of disease development remain largely unknown. Emerging evidence showed that non-coding RNAs (ncRNAs), namely microRNAs, long ncRNAs and circular RNAs, are deregulated in many orthopaedic diseases, including scoliosis. Importantly, these deregulated ncRNAs functionally participate in the initiation and progression of scoliosis. Here, we review recent progress in ncRNA research on scoliosis.
All Author(s) ListLi Z, Li X, Shen J, Zhang L, Chan MTV, Wu WKK
Journal nameCell Proliferation
Year2020
Month2
Volume Number53
Issue Number2
PublisherWiley
Article numbere12736
ISSN0960-7722
eISSN1365-2184
LanguagesEnglish-United Kingdom

Last updated on 2020-19-10 at 00:56