Differentially expressed circular RNAs in air pollution-exposed rat embryos
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AbstractCircular RNAs (circRNAs) are an important class of non-coding RNAs partly by acting as microRNA sponges. Growing evidence indicates that air pollution exposure during pregnancy could lead to congenital defects in the offspring. In this study, using circRNAs sequencing, we profiled differentially expressed circRNAs in rat embryos exposed to a high concentration (> 200 μg/m3) of fine particulate matter (PM2.5) in utero. Compared with the control embryos whose mothers were reared in clean air, 25 and 55 circRNAs were found to be downregulated and upregulated, respectively, in the air pollution–exposed group. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of circRNA-coexpressed genes indicated that segmentation, brain development, and system development together with lysine degradation, Rap1 signaling pathway, and adrenergic signaling were deregulated by in utero air pollution exposure. We also identified the central role of three circRNAs, namely circ_015003, circ_030724, and circ_127215 in the circRNA-microRNA interaction network. These data suggested that circRNA deregulation might play a crucial role in the development of air pollution–associated congenital malformations.
All Author(s) ListLi Z, Ma J, Shen J, Chan MTV, Wu WKK, Wu Z
Journal nameEnvironmental Science and Pollution Research
Year2019
Month11
Volume Number26
Issue Number33
Pages34421 - 34429
ISSN0944-1344
eISSN1614-7499
LanguagesEnglish-United Kingdom

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