Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration
Publication in refereed journal

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摘要Intervertebral disc degeneration (IDD) is a common cause of low back pain, which inflicts more global disability than any other condition. Although IDD was deemed to be a natural process that comes with ageing, a growing body of evidence suggested that both genetic and environmental factors could modify the development of IDD. In this connection, aberrant function of nucleus pulposus cells has been implicated in IDD pathogenesis. Circular RNAs are a novel class of endogenous non‐coding RNAs that play crucial regulatory roles in diverse cellular processes. Recently, deregulation of circRNAs in nucleus pulposus cells was found to functionally participate in IDD development. In this review, we summarize the current knowledge regarding the deregulation of circRNAs in IDD in relation to their actions on nucleus pulposus cell functions, including cell proliferation, apoptosis and extracellular matrix synthesis/degradation. The potential clinical utilities of circRNAs as therapeutic targets for the management of IDD are also discussed.
著者Li Z, Chen X, Xu D, Li S, Chan MTV, Wu WKK
期刊名稱Cell Proliferation
出版年份2019
月份11
卷號52
期次6
文章號碼e12704
國際標準期刊號0960-7722
電子國際標準期刊號1365-2184
語言英式英語

上次更新時間 2020-18-09 於 00:25