Maternal and Offspring Exposure to Perfluorooctane Sulfonate (PFOS) is associated with Maternal Hyperglycaemia and Adverse Neonatal and Childhood Outcomes
Refereed conference paper presented and published in conference proceedings


摘要Background/Aims: Perfluorooctane sulfonate (PFOS) belongs to a class of endocrine-disrupting chemicals known as perfluoroalkyl chemicals (PFCs) implicated in adiposity. Although supposedly phased out since 2002, its use remains widespread in Asia. We aim to examine the relationship between exposure to PFOS and long-term metabolic outcomes in the offspring.

Method: We measured blood PFOS and other PFCs in archived samples taken at 24-32weeks gestation from mothers in the Hong Kong centre of the Hyperglycaemia and Adverse Pregnancy Outcome (HAPO) study between 2002-2004. All mothers underwent 75g OGTT and GDM was diagnosed according to the IADPSG/WHO 2013 criteria. Pregnancy outcomes, neonatal anthropometrics and childhood outcomes at 7 years were documented (Tam WH et al, Diabetes Care 2017). PFCs were measured using high performance LC-MS-MS. We completed analysis of PFCs in 1,601 maternal samples, a subset of 99 cord blood samples, and samples from 970 offspring at 7 years follow-up.

Results: There is strong correlation among PFOS and other PFCs in cord blood (=0.51-0.74, p<0.001), as well as correlation with maternal levels (=0.60, p<0.001). Ratio of cord blood to maternal PFOS was 0.60. Using regression analysis with adjustment for maternal age, BMI, and offspring gender, maternal PFOS showed suggestive association with maternal glucose parameters during pregnancy. Log-transformed maternal PFOS was associated with higher birthweight, lower birth length, higher ponderal index and lower neonatal sum of skin fold thickness (beta -0.337 ± 0.085, p=7.1x 10-5), after adjustment for all covariates. Maternal PFOS during pregnancy was not associated with offspring glycaemic parameters or indices of beta-cell function. Log-transformed offspring PFOS levels and deciles of PFOS were associated with reduced renal function in the offspring.

Conclusions: Maternal and offspring PFOS levels were associated with adverse pregnancy outcome and offspring cardiometabolic profile. Exposure to PFOS may be an important contributing factor to the epidemic of hyperglycaemia in pregnancy and childhood metabolic disorders in Asia. (Supported by Health and Medical Research Fund (Ref. 13140761))
著者Ma RC, Tam CH, Ozaki R, Lowe WL Jnr., Metzger BE, Tam WH, Wong CKC
會議名稱The 11th DOHaD World Congress

上次更新時間 2020-04-06 於 12:40