Age-Related Changes in the Bone Marrow
Publication in refereed journal

替代計量分析
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其它資訊
摘要Purpose of Review
To summarize current knowledge with regards to age-related changes in the bone marrow from childhood to senility and discuss how these changes are affected in patients with osteoporosis.

Recent Findings
There is a dramatic increase in marrow fat content in females around the time of the menopause in line with a reduction in bone mass. Marrow fat content is very responsive to physiological changes in estrogen and increase in marrow fat can be reversed by estrogen replacement. Marrow fat composition, rather than content, seems to be related to insufficiency fracture and diabetes.

Summary
MR imaging is a very good way of non-invasively studying marrow fat changes throughout life—both content and composition. Marrow fat content is an inverse marker of red marrow content. Red marrow content drives bone perfusion. Bone perfusion affects marrow nutrition and bone healing. Research into the fascinating bone-fat-perfusion relationship has only just began.
著者JF Griffith
期刊名稱Current Radiology Reports
出版年份2017
月份6
卷號5
期次6
出版社Springer (part of Springer Nature): Springer Open Choice Hybrid Journals
文章號碼24
國際標準期刊號2167-4825
語言美式英語
關鍵詞Bone marrow, Marrow perfusion, Marrow fat, Marrow diffusion, Magnetic resonance imaging, Bone densitometry

上次更新時間 2020-18-11 於 23:06