Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys
Publication in refereed journal

替代計量分析
.

其它資訊
摘要In China, children aged <8 months, who were expected to be protected by maternal antibodies before receiving the first dose of measles vaccine, were the age group with the greatest risk of infection in recent years. In this study, we evaluated whether infants yet to be age-eligible for measles vaccine had a sufficient seropositive level of maternal measles antibodies in 2009 and 2013. Blood samples were collected from infants aged <8 months through population-based serological surveys conducted in Zhejiang, China. Serum levels of immunoglobulin G measles antibodies were quantified using enzyme-linked immunosorbent assay. In 2013, the mean geometric mean titres (GMTs) of infants aged 4 to 8 months were below the seropositivity threshold (<200 mIU/mL), decreasing from 118.6 mIU/mL (95% confidence interval [CI] 83.0, 169.3 mIU/mL) at 4 months to 28.6 mIU/mL (95% CI 15.6, 52.3 mIU/mL) at 7 months. Antibody levels were significantly lower in 2013 than in 2009 starting from 5 months of age. In conclusion, infants aged 4 to 8 months are susceptible to measles due to low levels of maternal measles antibodies. It is thus suggested to provide infants with a supplementary dose on top of the routine schedule, and/or launch catch-up vaccination campaigns among young women.
出版社接受日期21.11.2019
著者Chong KC, Rui Y, Liu Y, Zhou TY, Jia K, Wang MHT, Mohammad K, He HQ
期刊名稱International Journal of Environmental Research and Public Health
出版年份2019
月份12
日期1
卷號16
期次23
文章號碼4680
頁次1 - 8
國際標準期刊號1661-7827
語言英式英語
關鍵詞measles, infants, China, MV, serosurvey, maternal, waning, vaccine

上次更新時間 2021-18-02 於 23:18