Long-term exposure to ambient fine particles and gastrointestinal cancer mortality in Taiwan: A cohort study
Publication in refereed journal

替代計量分析
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其它資訊
摘要Background:
Information on the association between long-term exposure to PM2.5 and gastrointestinal cancer mortality is scarce.

Objectives:
This study investigated the association between long-term exposure to PM2.5 and deaths from gastrointestinal
cancer and its subtypes in adults in Taiwan.

Methods:
A total of 385,650 Taiwanese adults (≥18 years old) jointed a standard medical examination program between 2001 and 2014 and were followed up until 2016. Their vital data were obtained from the National Death Registry maintained by the Ministry of Health and Welfare in Taiwan. We estimated the ambient PM2.5 concentration at individual’s address utilising a satellite-based spatiotemporal model at a resolution of 1 km2. Cox proportional hazard regression model was used to investigate the associations between ambient PM2.5 and deaths from gastrointestinal, stomach, colorectal and liver cancers.

Results:
We found that each 10 μg/m3 increase in PM2.5 was associated with an increased hazard risk (HR) of 1.09 (95% confidence interval (CI): 1.03–1.16) and 1.13 (95%CI: 1.02–1.24) in deaths from gastrointestinal and liver cancers, respectively. The association between PM2.5 and death from colorectal cancer was marginally statistically significant [HR: 1.13 (95%CI: 1.00–1.26)]. We did not find significant associations between PM2.5 and mortality from stomach cancer.

Conclusions:
Long-term exposure to ambient PM2.5 was associated with an increased risk of deaths from gastrointestinal cancers, liver cancer and also potentially colorectal cancer. Air pollution control strategies are necessary to reduce the burden of gastrointestinal cancer.
出版社接受日期04.03.2020
著者Guo C, Chan TC, Teng YC, Lin CQ, Bo YC, Chang LY, Lau AKH, Tam T, Wong MCS, Lao XQ
期刊名稱Environment International
出版年份2020
月份5
卷號138
出版社Elsevier
文章號碼105640
國際標準期刊號0160-4120
語言英式英語
關鍵詞Long-term exposure, PM2.5 air pollution, Gastrointestinal cancer mortality, Live cancer mortality, Taiwan

上次更新時間 2020-19-10 於 00:54