Long-term exposure to ambient fine particles and gastrointestinal cancer mortality in Taiwan: A cohort study
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AbstractBackground:
Information on the association between long-term exposure to PM2.5 and gastrointestinal cancer mortality is scarce.

Objectives:
This study investigated the association between long-term exposure to PM2.5 and deaths from gastrointestinal
cancer and its subtypes in adults in Taiwan.

Methods:
A total of 385,650 Taiwanese adults (≥18 years old) jointed a standard medical examination program between 2001 and 2014 and were followed up until 2016. Their vital data were obtained from the National Death Registry maintained by the Ministry of Health and Welfare in Taiwan. We estimated the ambient PM2.5 concentration at individual’s address utilising a satellite-based spatiotemporal model at a resolution of 1 km2. Cox proportional hazard regression model was used to investigate the associations between ambient PM2.5 and deaths from gastrointestinal, stomach, colorectal and liver cancers.

Results:
We found that each 10 μg/m3 increase in PM2.5 was associated with an increased hazard risk (HR) of 1.09 (95% confidence interval (CI): 1.03–1.16) and 1.13 (95%CI: 1.02–1.24) in deaths from gastrointestinal and liver cancers, respectively. The association between PM2.5 and death from colorectal cancer was marginally statistically significant [HR: 1.13 (95%CI: 1.00–1.26)]. We did not find significant associations between PM2.5 and mortality from stomach cancer.

Conclusions:
Long-term exposure to ambient PM2.5 was associated with an increased risk of deaths from gastrointestinal cancers, liver cancer and also potentially colorectal cancer. Air pollution control strategies are necessary to reduce the burden of gastrointestinal cancer.
Acceptance Date04/03/2020
All Author(s) ListGuo C, Chan TC, Teng YC, Lin CQ, Bo YC, Chang LY, Lau AKH, Tam T, Wong MCS, Lao XQ
Journal nameEnvironment International
Year2020
Month5
Volume Number138
PublisherElsevier
Article number105640
ISSN0160-4120
LanguagesEnglish-United Kingdom
KeywordsLong-term exposure, PM2.5 air pollution, Gastrointestinal cancer mortality, Live cancer mortality, Taiwan

Last updated on 2021-20-01 at 00:01