Long-Term Exposure to Ambient Fine Particulate Matter (PM2.5) and Lung Function in Children, Adolescents, and Young Adults: A Longitudinal Cohort Study
Publication in refereed journal

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其它資訊
摘要BACKGROUND:
The association between long-term exposure to ambient fine particulate matter with aerodynamic diameter ≤2:5 um (PM2.5) and lung function in young people remains uncertain, particularly in Asia, where air pollution is generally a serious problem.

OBJECTIVES:
This study investigated the association between long-term exposure to ambient PM2.5 and lung function in Taiwanese children, adolescents, and young adults.

METHODS:
This study comprised 24,544 participants 6–24 years of age, with 33,506 medical observations made between 2000 and 2014. We used a spatio temporal model to estimatePM2.5 concentrations at participants’ addresses. Spirometry parameters, i.e., forced vital capacity (FVC), forced expiratory volume in 1s (FEV1), and maximum mid-expiratory flow (MMEF), were determined. A generalized linear mixed model was used to examine the associations between long-term exposure to ambient PM2.5 and lung function. The odds ratios (ORs) of poor lung function were also calculated after adjusting for a range of covariates.

RESULTS: Every 10-lg=m3 increase in the 2-y average PM2.5 concentration was associated with decreases of 2.22% [95% confidence interval(CI): −2:60, −1:85], 2.94(95%CI: −3:36, −2:51), and 2.79%(95%CI: −3:15, −2:41) in the FVC, FEV1, and MMEF, respectively. Furthermore, it was associated with a 20%increase in the prevalence of poor lung function (OR: 1.20; 95% CI: 1.12,1.29).

CONCLUSIONS:
Two-year ambient PM2.5 concentrations were inversely associated with lung function and positively associated with the prevalence of poor lung function in children, adolescents, and young adults in Taiwan.
出版社接受日期02.12.2019
著者Guo C, Hoek G, Chang LY, Bo YC, Lin CQ, Huang B, Chan TC, Tam T, Lau AKH, Lao XQ
期刊名稱Environmental Health Perspectives
出版年份2019
月份12
卷號127
期次12
文章號碼127008
頁次1 - 9
國際標準期刊號0091-6765
電子國際標準期刊號1552-9924
語言英式英語

上次更新時間 2020-06-08 於 00:41