Can we enhance osteoporotic metaphyseal fracture healing through enhancing ultrastructural and functional changes of osteocytes in cortical bone with low-magnitude high-frequency vibration?
Publication in refereed journal

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其它資訊
摘要Fragility fractures are related to the loss of bone integrity and deteriorated morphology of osteocytes. Our previous studies have reported that low-magnitude high-frequency vibration (LMHFV) promoted osteoporotic fracture healing. As osteocytes are known for mechanosensing and initiating bone repair, we hypothesized that LMHFV could enhance osteoporotic fracture healing through enhancing morphological changes in the osteocyte lacuna-canalicular network (LCN) and mineralization. A metaphyseal fracture model was established in female Sprague-Dawley rats to investigate changes in osteocytes and healing outcomes from early to late phase post-fracture. Our results showed that the LCN exhibited an exuberant outgrowth of canaliculi in the osteoporotic fractured bone at day 14 after LMHFV. LMHFV upregulated the E11, dentin matrix protein 1 (DMP1), and fibroblast growth factor 23 (FGF23), but downregulated sclerostin (Sost) in osteocytes. Moreover, LMHFV promoted mineralization with significant enhancements of Ca/P ratio, mineral apposition rate (MAR), mineralizing surface (MS/BS), and bone mineral density (BMD) in the osteoporotic group. Consistently, better healing was confirmed by microarchitecture and mechanical properties, whereas the enhancement in osteoporotic group was comparable or even greater than the normal group. This is the first report to reveal the enhancement effect of LMHFV on the osteocytes' morphology and functions in osteoporotic fracture healing.
出版社接受日期07.01.2020
著者Man-Huen Victoria Choy, Ronald Man-Yeung Wong, Meng-Chen Li, Bai Yan Wang, Xiao Dong Liu, Wayne Lee, Jack Chun-Yiu Cheng, Simon Kwoon-Ho Chow, Wing-Hoi Cheung
期刊名稱FASEB Journal
出版年份2020
月份3
卷號34
期次3
頁次4234 - 4252
國際標準期刊號0892-6638
電子國際標準期刊號1530-6860
語言英式英語
關鍵詞lacuna-canalicular network (LCN), mechanical loading, osteocytes, osteoporotic fracture healing, vibration

上次更新時間 2020-26-11 於 23:53