Wild Melon Seed Oil Reduces Plasma Cholesterol and Modulates Gut Microbiota in Hypercholesterolemic Hamsters
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摘要Wild melon (Cucumis melo var. agrestis) seed oil (CO) contains 71.3% polyunsaturated fatty acids. The present study investigated the effects of CO on blood cholesterol and gut microbiota. Hamsters (n = 32) were randomly divided into four groups and given one of four diets, namely noncholesterol diet (NCD), high-cholesterol diet containing 0.1% cholesterol (HCD), HCD containing 4.75% CO (COL), and HCD containing 9.5% CO (COH) for 6 weeks. CO supplementation at 9.5% in the diet reduced plasma cholesterol by 24% and enhanced the excretion of fecal bile acids by 150%. CO supplementation upregulated the gene expression of hepatic cholesterol 7α-hydroxylase (CYP7A1). In addition, supplementation of CO in the diet remarkably increased the production of fecal short-chain fatty acids and favorably altered the relative abundances of Eubacteriaceae, Clostridiales_vadinBB60_group, Ruminococcaceae, Streptococcaceae, and Desulfovibrionaceae at a family level. It was concluded that CO could reduce plasma cholesterol via promoting the excretion of fecal acidic sterols and modulating gut microbiota.
出版社接受日期27.01.2020
著者Wangjun Hao, Hanyue Zhu, Jingnan Chen, Erika Kwek, Zouyan He, Jianhui Liu, Ning Ma, Ka Ying Ma, Zhen-Yu Chen
期刊名稱Journal of Agricultural and Food Chemistry
出版年份2020
月份2
日期19
卷號68
期次7
頁次2071 - 2081
國際標準期刊號0021-8561
電子國際標準期刊號1520-5118
語言美式英語
關鍵詞Cucumis melo var. agrestis, wild melon seed oil, hypercholesterolemia, cholesterol metabolism, gut microbiota

上次更新時間 2020-01-08 於 02:01