Wild Melon Seed Oil Reduces Plasma Cholesterol and Modulates Gut Microbiota in Hypercholesterolemic Hamsters
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AbstractWild melon (Cucumis melo var. agrestis) seed oil (CO) contains 71.3% polyunsaturated fatty acids. The present study investigated the effects of CO on blood cholesterol and gut microbiota. Hamsters (n = 32) were randomly divided into four groups and given one of four diets, namely noncholesterol diet (NCD), high-cholesterol diet containing 0.1% cholesterol (HCD), HCD containing 4.75% CO (COL), and HCD containing 9.5% CO (COH) for 6 weeks. CO supplementation at 9.5% in the diet reduced plasma cholesterol by 24% and enhanced the excretion of fecal bile acids by 150%. CO supplementation upregulated the gene expression of hepatic cholesterol 7α-hydroxylase (CYP7A1). In addition, supplementation of CO in the diet remarkably increased the production of fecal short-chain fatty acids and favorably altered the relative abundances of Eubacteriaceae, Clostridiales_vadinBB60_group, Ruminococcaceae, Streptococcaceae, and Desulfovibrionaceae at a family level. It was concluded that CO could reduce plasma cholesterol via promoting the excretion of fecal acidic sterols and modulating gut microbiota.
Acceptance Date27/01/2020
All Author(s) ListWangjun Hao, Hanyue Zhu, Jingnan Chen, Erika Kwek, Zouyan He, Jianhui Liu, Ning Ma, Ka Ying Ma, Zhen-Yu Chen
Journal nameJournal of Agricultural and Food Chemistry
Year2020
Month2
Day19
Volume Number68
Issue Number7
Pages2071 - 2081
ISSN0021-8561
eISSN1520-5118
LanguagesEnglish-United States
KeywordsCucumis melo var. agrestis, wild melon seed oil, hypercholesterolemia, cholesterol metabolism, gut microbiota

Last updated on 2020-21-03 at 23:28