Beneficial Effects of Dietary Polyphenols on High-Fat Diet-Induced Obesity Linking with Modulation of Gut Microbiota
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AbstractObesity is caused by an imbalance of energy intake and expenditure. It is characterized by a higher accumulation of body fat with a chronic low-grade inflammation. Many reports have shown that gut microbiota in the host plays a pivotal role in mediating the interaction between consumption of a high-fat diet (HFD) and onset of obesity. Accumulative evidence has suggested that the changes in the composition of gut microbiota may affect the host’s energy homeostasis, systemic inflammation, lipid metabolism, and insulin sensitivity. As one of the major components in human diet, polyphenols have demonstrated to be capable of modulating the composition of gut microbiota and reducing the HFD-induced obesity. The present review summarizes the findings of recent studies on dietary polyphenols regarding their metabolism and interaction with bacteria in the intestine as well as the underlying mechanisms by which they modulate the gut microbiota and alleviate the HFD-induced obesity.
Acceptance Date12/12/2019
All Author(s) ListJianhui Liu, Zouyan He, Ning Ma, Zhen-Yu Chen
Journal nameJournal of Agricultural and Food Chemistry
Volume Number68
Issue Number1
Pages33 - 47
LanguagesEnglish-United States
Keywordsgut microbiota, high-fat diet, inflammation, obesity, polyphenols

Last updated on 2021-09-06 at 23:58