Drug hypersensitivity reactions in Asia: regional issues and challenges
Publication in refereed journal

香港中文大學研究人員

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摘要There are geographical, regional, and ethnic differences in the phenotypes and endotypes of patients with drug hypersensitivity reactions (DHRs) in different parts of the world. In Asia, aspects of drug hypersensitivity of regional importance include IgE-mediated allergies and T-cell-mediated reactions, including severe cutaneous adverse reactions (SCARs), to beta-lactam antibiotics, antituberculous drugs, nonsteroidal anti-inflammatory drugs (NSAIDs) and radiocontrast agents. Delabeling of low-risk penicillin allergy using direct oral provocation tests without skin tests have been found to be useful where the drug plausibility of the index reaction is low. Genetic risk associations of relevance to Asia include human leucocyte antigen (HLA)-B*1502 with carbamazepine SCAR, and HLA-B*5801 with allopurinol SCAR in some Asian ethnic groups. There remains a lack of safe and accurate diagnostic tests for antituberculous drug allergy, other than relatively high-risk desensitization regimes to first-line antituberculous therapy. NSAID hypersensitivity is common among both adults and children in Asia, with regional differences in phenotype especially among adults. Low dose aspirin desensitization is an important therapeutic modality in individuals with cross-reactive NSAID hypersensitivity and coronary artery disease following percutaneous coronary intervention. Skin testing allows patients with radiocontrast media hypersensitivity to confirm the suspected agent and test for alternatives, especially when contrasted scans are needed for future monitoring of disease relapse or progression, especially cancers.
著者Bernard Yu-Hor Thong, Michaela Lucas, Hye-Ryun Kang, Yoon-Seok Chang, Philip Hei Li, Min Moon Tang, James Yun, Jie Shen Fok, Byung-Keun Kim, Mizuho Nagao, Iris Rengganis, Yi-Giien Tsai, Wen-Hung Chung, Masao Yamaguchi, Ticha Rerkpattanapipat, Wasu Kamchaisatian, Ting Fan Leung, Ho Joo Yoon, Luo Zhang, Amir Hamzah Abdul Latiff, Takao Fujisawa, Francis Thien, Mariana C. Castells, Pascal Demoly, Jiu-Yao Wang, Ruby Pawankar
期刊名稱Asia Pacific Allergy
出版年份2020
月份1
卷號10
期次1
出版社Asia Pacific Association of Allergy, Asthma and Clinical Immunology
出版地South Korea
文章號碼e8
國際標準期刊號2233-8276
電子國際標準期刊號2233-8268
語言美式英語
關鍵詞Anaphylaxis, asthma, drugs, hypersensitivity, pharmacogenetics

上次更新時間 2020-01-08 於 02:06