Effect of differentially expressed LBX1 in adolescent idiopathic scoliosis (AIS) paraspinal muscle phenotypes via modulating myoblasts
Refereed conference paper presented and published in conference proceedings


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摘要AIS is a three-dimensional spinal deformity with unclear etiopathogenesis. LBX1 is so far the only multi-centers validated AIS predisposing gene. The posterior paraspinal muscles provide dynamic stability to the spinal column and their imbalance has been speculated as an important factor in AIS etiopathogenesis. It is poorly understood how LBX1 contribute to the abnormal paraspinal muscle phenotypes and onset/progression of AIS. This study aims to: 1, Investigate the expression of LBX1 and muscle fiber types distribution, myogenic markers in concave and convex apical paraspinal muscle in AIS by comparing with age- and curve severity-matched congenital scoliosis (CS) patients; 2, Explore the biological function of LBX1 on HSMM (human skeletal muscle myoblast) myogenic activity via gain-of-function cellular study.
出版社接受日期01.11.2019
著者YJ Wang, ZH Feng, KL Cheng, JJ Zhang, LL Xu, TP Lam, Alec Hung, Jack CY Cheng, Y. Qiu, Wayne Lee
會議名稱The 14th Annual Congress of Chinese Orthopaedic Association
會議開始日14.11.2019
會議完結日17.11.2019
會議地點Shanghai
會議國家/地區中國
出版年份2019
月份11
日期14
語言英式英語

上次更新時間 2020-01-06 於 14:37