Effect of differentially expressed LBX1 in adolescent idiopathic scoliosis (AIS) paraspinal muscle phenotypes via modulating myoblasts
Refereed conference paper presented and published in conference proceedings


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AbstractAIS is a three-dimensional spinal deformity with unclear etiopathogenesis. LBX1 is so far the only multi-centers validated AIS predisposing gene. The posterior paraspinal muscles provide dynamic stability to the spinal column and their imbalance has been speculated as an important factor in AIS etiopathogenesis. It is poorly understood how LBX1 contribute to the abnormal paraspinal muscle phenotypes and onset/progression of AIS. This study aims to: 1, Investigate the expression of LBX1 and muscle fiber types distribution, myogenic markers in concave and convex apical paraspinal muscle in AIS by comparing with age- and curve severity-matched congenital scoliosis (CS) patients; 2, Explore the biological function of LBX1 on HSMM (human skeletal muscle myoblast) myogenic activity via gain-of-function cellular study.
Acceptance Date01/11/2019
All Author(s) ListYJ Wang, ZH Feng, KL Cheng, JJ Zhang, LL Xu, TP Lam, Alec Hung, Jack CY Cheng, Y. Qiu, Wayne Lee
Name of ConferenceThe 14th Annual Congress of Chinese Orthopaedic Association
Start Date of Conference14/11/2019
End Date of Conference17/11/2019
Place of ConferenceShanghai
Country/Region of ConferenceChina
Year2019
Month11
Day14
LanguagesEnglish-United Kingdom

Last updated on 2020-01-06 at 14:37