Accuracy of Ultrasound for Radiation-free Quantitative Assessment of Spinal Curvatures in Patients with Idiopathic Scoliosis: A Systematic Review and Meta-analysis
Refereed conference paper presented and published in conference proceedings


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AbstractIntroduction: Despite application of ultrasound for quantitative measurement of spinal curvatures has been reported with various studies, a systematic review for such is lacking. This systematic review aimed to evaluate the reliability and validity of ultrasound, using radiographic measurement as gold standard in idiopathic scoliosis patients, and the use of various anatomical landmarks for measurement of spinal curvatures.
Methods: Medline, Embase, CINAHL, and CENTRAL databases were searched. QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies 2) quality assessment tool was adopted. Reliability of ultrasound in terms of intra-class correlation coefficient was recorded. Pearson correlation coefficients between ultrasound and radiographic measurements were extracted for meta-analysis. Subgroup analyses based on ultrasound measurement protocols of spinous process (SP), transverse processes (TP), and centre of lamina (COL) were conducted.
Results: Eleven articles reporting 18 correlation analyses on 766 subjects were eligible for meta-analysis. The mean interrater reliability of ultrasound measurement was 0.87 ± 0.07. Pooled correlation for all studies was 0.918 (95% confidence interval=0.868-0.949), exhibiting substantial heterogeneity (I2=90.50%, p<0.001). Subgroup analyses showed that pooled correlations were 0.887 for COL method (comprising 356 subjects); 0.924 for SP method (255 subjects); and 0.941 for TP method (117 subjects); all with notable heterogeneity (I2>90%, p<0.001). The overall risk of bias was rated moderate; yet publication bias was noted.
Conclusions: Our results show that ultrasound is a promising non-invasive method with satisfactory validity and reliability for measuring coronal curvatures using the SP, TP, or COL methods. Further development of three-dimensional ultrasound towards scoliosis assessment will facilitate its translational application for managing scoliosis.
Acceptance Date02/10/2019
All Author(s) ListYS Wong, KKL Lai, YP Zheng, H Pang, JCY Cheng, TP Lam
Name of ConferenceHong Kong Orthopaedic Association 39th Annual Congress 2019 (HKOA 2019)
Start Date of Conference02/11/2019
End Date of Conference03/11/2019
Place of ConferenceHong Kong
Country/Region of ConferenceHong Kong
Year2019
Month11
Day2
Place of PublicationHong Kong
LanguagesEnglish-United Kingdom

Last updated on 2020-29-05 at 11:32