Composite Model to Predict Curve Severity of Adolescent Idiopathic Scoliosis: A 6-Year Longitudinal Study beyond Skeletal Maturity
Refereed conference paper presented and published in conference proceedings


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摘要Introduction: The aetiopathogenesis of adolescent idiopathic scoliosis (AIS) remains unclear. Early risk evaluation of curve severity for timely intervention is important. We previously reported miR-145-5p in AIS osteoblasts impairing osteocytogenic differentiation and we have discussed the clinical implication of serological markers in a small sample size cohort. In the present study, we aimed to evaluate the prognostic value of a composite model in predicting curve severity.
Methods: This was a 6-year longitudinal cohort study. Girls with AIS (n=100) were recruited at their first visit to our clinic. We took blood samples and measured anthropometry and curve severity. The patients with AIS were followed up clinically every 6 months for 6 years. Severe AIS was defined as Cobb’s angle >40°. Serum CTX/P1NP and plasma miRNA level were determined.
Results: Thirty patients had severe AIS at the end of the 6-year study. Patients with severe AIS had significantly higher serum levels of P1NP and significantly lower plasma levels of miR-145 compared with patients with AIS with Cobb’s angle <40°. Plasma miR-145 levels showed negative correlation with Cobb’s angle (p=0.002). Using clinical anthropometric parameters, serum P1NP, and plasma miR-145, our composite model showed outstanding power to predict curve severity with R2 0.575 and hazard ratio of 14.506.
Conclusion: The composite model constructed in this study can guide decision making and disease management at an early stage of AIS to help prevent progression of spinal deformity.
出版社接受日期02.10.2019
著者JJ Zhang, KY Cheuk, ALH Hung, TP Lam, JCY Cheng, WYW Lee
會議名稱Hong Kong Orthopaedic Association 39th Annual Congress 2019 (HKOA 2019)
會議開始日02.11.2019
會議完結日03.11.2019
會議地點Hong Kong
會議國家/地區香港
出版年份2019
月份11
日期2
出版地Hong Kong
語言英式英語

上次更新時間 2020-29-05 於 11:19