Aberrant Circulating Wnt16 Expression in Adolescent Idiopathic Scoliosis
Refereed conference paper presented and published in conference proceedings


摘要Introduction: Low bone mass is a systemic and persistent condition in adolescent idiopathic scoliosis (AIS). Wnt16 was recently reported to be a key determinant of cortical bone thickness. We investigated whether Wnt16 affects bone remodelling in AIS, which could result in reduced cortical bone quality.
Methods: In total, 74 patients with AIS (age 13.71 ± 1.39 years) and 73 control patients (age 14.17 ± 1.02 years) were recruited. Anthropometric parameters were measured with standard stadiometry techniques, and bone quality were assessed with dual-energy X-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HR-pQCT). Multiple selective circulatory bone markers were measured with multiplex assays and Wnt16 was measured with enzymelinked immunosorbent assay. Comparisons between groups and correlation analysis within each group were performed with SPSS.
Results: The DXA (Z-score of femoral neck areal bone mineral density) and HR-pQCT (total and cortical volumetric bone mineral density and thickness) parameters showed significantly lower bone mineral density in patients with AIS compared with control patients. Patients with AIS (Cobb’s angle of 29.00 ± 13.22°) had lower circulatory levels of Wnt16, but significantly higher levels of P1NP and osteocalcin (bone formation markers). In the control group, circulatory Wnt16 was positively and significantly correlated with circulatory levels of sclerostin and DKK-1 (Wnt signalling antagonists); this association was less apparent in patients with AIS.
Conclusion: This is the first study demonstrating an aberrant Wnt16 expression level in patients with AIS. Further validation studies with larger cohorts with different severities and in-depth mechanistic studies are warranted.
著者KL Cheng, QQ Li, TP Lam, JCY Cheng, WYW Lee
會議名稱Hong Kong Orthopaedic Association 39th Annual Congress 2019 (HKOA 2019)
會議地點Hong Kong
出版地Hong Kong

上次更新時間 2020-29-05 於 11:04