Frequent Integration of HBV DNA in Genomes of Hepatocellular Carcinoma Cells From Patients With Occult Infections
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AbstractOccult hepatitis B infection (OBI) is a state of undetectable serum hepatitis B surface antigen (HBsAg), yet with detectable serum or intrahepatic hepatitis B virus (HBV) DNA.1,2 In the vast majority of cases, OBI is also characterized by a long-lasting persistence of low-level replication competent HBV DNA (ie, the episomal HBV covalently closed circular DNA [cccDNA]).2 Although largely under explored, OBI is thought to increase the risk of hepatocellular carcinoma (HCC). It is known that repeated liver damage and regeneration caused by persistent necroinflammation plays a major role in chronic HBV infection–related HCC, and consequentially, the majority of patients have underlying liver cirrhosis.
All Author(s) ListWong N
Journal nameClinical Gastroenterology and Hepatology
Volume Number18
Issue Number2
Pages302 - 303
LanguagesEnglish-United Kingdom

Last updated on 2020-31-03 at 00:26