The Maturation Pathway of Nickel Urease
Publication in refereed journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要Maturation of urease involves post-translational insertion of nickel ions to form an active site with a carbamylated lysine ligand and is assisted by urease accessory proteins UreD, UreE, UreF and UreG. Here, we review our current understandings on how these urease accessory proteins facilitate the urease maturation. The urease maturation pathway involves the transfer of Ni2+ from UreE → UreG → UreF/UreD → urease. To avoid the release of the toxic metal to the cytoplasm, Ni2+ is transferred from one urease accessory protein to another through specific protein–protein interactions. One central theme depicts the role of guanosine triphosphate (GTP) binding/hydrolysis in regulating the binding/release of nickel ions and the formation of the protein complexes. The urease and [NiFe]-hydrogenase maturation pathways cross-talk with each other as UreE receives Ni2+ from hydrogenase maturation factor HypA. Finally, the druggability of the urease maturation pathway is reviewed.
出版社接受日期04.07.2019
著者Yap Shing Nim, Kam Bo Wong
期刊名稱Inorganics
出版年份2019
月份7
卷號7
期次7
出版社MDPI
文章號碼85
國際標準期刊號2304-6740
語言美式英語

上次更新時間 2020-25-09 於 12:24