Nature and specificity of altered cognitive functioning in IBS
Publication in refereed journal

替代計量分析
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其它資訊
摘要Background:
It is unknown whether cognitive dysfunction found in patients with irritable bowel syndrome (IBS) was attributable to the different subtypes, ongoing pathophysiological processes, trait characteristics, or psychiatric comorbidity.

Methods:
Forty Rome‐III patients with IBS (20 diarrhea‐predominant [IBS‐D] and 20 constipation‐predominant [IBS‐C]) and 40 age‐, sex‐, education‐matched healthy controls were systematically recruited and compared on their cognitive function with continuous performance test (CPT), Wisconsin Card Sorting Test (WCST) and emotional Stroop test. Beck Anxiety Inventory (BAI), Beck Depression Inventory‐II (BDI‐II), Patient Health Questionnaire‐15 (PHQ‐15) and a structured bowel symptom questionnaire were performed to measure anxiety, depressive, somatization, and bowel symptoms, respectively. Psychiatric diagnoses were ascertained with SCID‐I (Structured Clinical Interview for DSM‐IV Axis I Disorders).

Key Results:
Patients with IBS showed significantly increased standard deviation of reaction time (SDRT) (P = .003) on CPT, increased failure to maintain set (FMS) (P=.002), and percentage of perseverative errors (P = .003) on WCST. SDRT did not correlate with illness chronicity or bowel symptoms. FMS correlated with bowel symptom severity. In logistic regression models controlled for BAI, BDI‐II, and PHQ‐15, SDRT (AOR = 1.08, P = .025), but not FMS (P = .25) or percentage of perseverative errors (P = .24), significantly differentiated IBS from controls. Cognitive function was not significantly different between IBS‐C and IBS‐D (P > .05), or between pure IBS (n = 22) and IBS with generalized anxiety disorder (GAD) (n = 17) (P > .05).

Conclusions & Inferences:
Patients with IBS showed attentional and executive function impairment irrespective of subtypes but otherwise heterogeneous in terms of its state‐trait correlations and overlap with anxiety comorbidity.
出版社接受日期23.07.2019
著者KMF Wong, ADP Mak, SY Yuen, ONW Leung, DY Ma, Y Chan, PK Cheong, R Lui, SH Wong, JCY Wu
期刊名稱Neurogastroenterology and Motility
出版年份2019
月份11
卷號31
期次11
文章號碼e13696
國際標準期刊號1350-1925
語言美式英語

上次更新時間 2020-25-10 於 00:29