Challenges and choices in the pharmacological treatment of non-severe pediatric asthma: A commentary for the practicing physician
Publication in refereed journal

香港中文大學研究人員
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摘要In recent years, asthma research has focused intensely on the severe part of the disease spectrum, leading to new treatments, mostly therapeutic monoclonal antibodies. However, severe asthma accounts for not more than 2% of asthma in the pediatric population. Therefore, non-severe asthma remains a major health problem in children, not only for patients and parents but also for healthcare professionals such as general practitioners, pediatricians and allergists who take care of these patients. It is thus essential to identify and put in context novel concepts, applicable to the treatment of these patients. Recent evidence suggests benefits from using anti-inflammatory treatment even for the mildest cases, for whom until now only symptomatic bronchodilation was recommended. Likewise, “reliever” medication may be better combined with an inhaled corticosteroid (ICS). Among “new” treatments (for children), ICS formulation in ultrafine particles has showed promise and tiotropium is gaining access to the pediatric population. Maintenance and reliever therapy (MART) is an option for moderate disease. Most importantly, personalized response to medications appears to be considerable, therefore, it may need to be taken into account. Overall, these new options provide opportunities for multiple new management strategies. The deployment of such strategies in different populations remains to be evaluated.
出版社接受日期31.07.2019
著者Omer Kalayci, Hanan Abdelateef, Cesar Fireth Pozo Beltran, Zeinab A. El-Sayed, Rene Maximiliano Gomez, Elham Hossny, Mario Morais-Almeida, Antonio Nieto, Wanda Phipatanakul, Paulo Pitrez, Gary WK Wong, Paraskevi Xepapadaki, Nikolaos G Papadopoulos
期刊名稱World Allergy Organization Journal
出版年份2019
月份9
卷號12
期次9
出版社Elsevier Inc.
文章號碼100054
國際標準期刊號1939-4551
語言美式英語
關鍵詞Mild asthma, Moderate asthma, Pharmacotherapy, MART, Treatment

上次更新時間 2020-12-08 於 00:12