Gut microbiome and brain functional connectivity in infants-a preliminary study focusing on the amygdala
Publication in refereed journal


Times Cited
Altmetrics Information
.

Other information
AbstractRecently, there has been a surge of interest in the possibility that microbial communities inhabiting the human gut could affect cognitive development and increase risk for mental illness via the microbiome-gut-brain axis. Infancy likely represents a critical period for the establishment of these relationships, as it is the most dynamic stage of postnatal brain development and a key period in the maturation of the microbiome. Indeed, recent reports indicate that characteristics of the infant gut microbiome are associated with both temperament and cognitive performance. The neural circuits underlying these relationships have not yet been delineated. To address this gap, resting-state fMRI scans were acquired from 39 1-year-old human infants who had provided fecal samples for identification and relative quantification of bacterial taxa. Measures of alpha diversity were generated and tested for associations with measures of functional connectivity. Primary analyses focused on the amygdala as manipulation of the gut microbiota in animal models alters the structure and neurochemistry of this brain region. Secondary analyses explored functional connectivity of nine canonical resting-state functional networks. Alpha diversity was significantly associated with functional connectivity between the amygdala and thalamus and between the anterior cingulate cortex and anterior insula. These regions play an important role in processing/responding to threat. Alpha diversity was also associated with functional connectivity between the supplementary motor area (SMA, representing the sensorimotor network) and the inferior parietal lobule (IPL). Importantly, SMA-IPL connectivity also related to cognitive outcomes at 2years of age, suggesting a potential pathway linking gut microbiome diversity and cognitive outcomes during infancy. These results provide exciting new insights into the gut-brain axis during early human development and should stimulate further studies into whether microbiome-associated changes in brain circuitry influence later risk for psychopathology.
All Author(s) ListGao W, Salzwedel AP, Carlson AL, Xia K, Azcarate-Peril MA, Styner MA, Thompson AL, Geng XJ, Goldman BD, Gilmore JH, Knickmeyer RC
Journal namePsychopharmacology
Year2019
Month5
Volume Number236
Issue Number5
PublisherSPRINGER
Pages1641 - 1651
ISSN0033-3158
LanguagesEnglish-United Kingdom
KeywordsAmygdala, Functional connectivity, Gut microbiome, Infant brain development
Web of Science Subject CategoriesNeurosciences;Pharmacology & Pharmacy;Psychiatry;Neurosciences & Neurology;Pharmacology & Pharmacy;Psychiatry

Last updated on 2020-12-09 at 00:00