Characterization of the fusion hybrids between adipose-derived stem cells and breast cancer cells
Refereed conference paper presented and published in conference proceedings

香港中文大學研究人員

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摘要Adipose-derived stem cells (ADSCs) are a type of mesenchymal stem cells isolated from adipose tissue and have the ability to differentiate into adipogenic, osteogenic and chondrogenic lineages. Despite their great therapeutic potentials, ADSCs were found to enhance breast cancer proliferation and metastatic potentials. Previously our lab has demonstrated the formation of ADSCs – breast cancer cells fusion hybrid using a mouse model. Our data showed this hybrid possesses some characteristics of cancer stem cells and we postulate that it may initiate tumor formation. In vivo xenograft study indicated that the tumorigenicity of the fusion hybrids was significantly higher than that of the parent triple negative breast cancer cell line MDA-MB-231. We also found that there are differences in the fusion efficiency between MDA-MB-231 and MCF-7 with ADSCs. However, the mechanism behind still needs to be elucidated.
著者Yuk Wah Chan, Chun So, Ka Long Yau, Kung Chun Chiu, Xiya Wang, Suk Ying Tsang
會議名稱The Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2019
會議開始日08.06.2019
會議完結日08.06.2019
會議地點Hong Kong
會議國家/地區香港
會議論文集題名The Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2019
出版年份2019
月份6
日期8
語言英式英語

上次更新時間 2020-20-05 於 10:56