Characterization of the fusion hybrids between adipose-derived stem cells and breast cancer cells
Refereed conference paper presented and published in conference proceedings


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AbstractAdipose-derived stem cells (ADSCs) are a type of mesenchymal stem cells isolated from adipose tissue and have the ability to differentiate into adipogenic, osteogenic and chondrogenic lineages. Despite their great therapeutic potentials, ADSCs were found to enhance breast cancer proliferation and metastatic potentials. Previously our lab has demonstrated the formation of ADSCs – breast cancer cells fusion hybrid using a mouse model. Our data showed this hybrid possesses some characteristics of cancer stem cells and we postulate that it may initiate tumor formation. In vivo xenograft study indicated that the tumorigenicity of the fusion hybrids was significantly higher than that of the parent triple negative breast cancer cell line MDA-MB-231. We also found that there are differences in the fusion efficiency between MDA-MB-231 and MCF-7 with ADSCs. However, the mechanism behind still needs to be elucidated.
All Author(s) ListYuk Wah Chan, Chun So, Ka Long Yau, Kung Chun Chiu, Xiya Wang, Suk Ying Tsang
Name of ConferenceThe Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2019
Start Date of Conference08/06/2019
End Date of Conference08/06/2019
Place of ConferenceHong Kong
Country/Region of ConferenceHong Kong
Proceedings TitleThe Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2019
Year2019
Month6
Day8
LanguagesEnglish-United Kingdom

Last updated on 2020-20-05 at 10:56