Role of TRPA1 in embryonic stem cell-derived cardiomyocytes
Refereed conference paper presented and published in conference proceedings



摘要Transient receptor potential (TRP) channels are broadly expressed in a variety of tissues and cell types. They are able to respond to a wide range of stimuli in the cellular environment, which makes them act as cellular vanguard sensors involved in nociception, taste perception, temperature and osmolarity sensation. Among TRP channels, TRP ankyrin 1 (TPRA1) channel was initially described as a cold-sensitive non-selective cation channel expressed in neuron. Recently, emerging evidence indicates that TRPA1 is expressed in various cell types including cardiomyocytes (CMs) and plays an important role in CM contractile function. Mouse embryonic stem cells (mESCs) are able to self-renew and maintain pluripotency to differentiate into all cell lineages including CMs. Thus, mESCs may provide an unlimited supply of cells for cell-based therapies. Up till now, there is limited knowledge on how TRPA1 regulates intracellular calcium [Ca2+]i of CMs. Our preliminary results indicated that mESC-derived CMs (mESC-CMs) expressed TRPA1. In addition, we found that the activities of TRPA1 are positively associated with the Ca2+ transients (CaTs) in mESC-CMs. However, the exact mechanism of how TRPA1 affects the CaTs is still under investigation. This current study shall provide novel information on the functional role of TRPA1 in CMs.
著者Qianqian Ding, Suk Ying Tsang
會議名稱The Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2019
會議地點Hong Kong
會議論文集題名The Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences 2019

上次更新時間 2020-20-05 於 10:46