Vascular Endothelial Cell Biology: An Update
Publication in refereed journal

替代計量分析
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其它資訊
摘要The vascular endothelium, a monolayer of endothelial cells (EC), constitutes the inner cellular lining of arteries, veins and capillaries and therefore is in direct contact with the components and cells of blood. The endothelium is not only a mere barrier between blood and tissues but also an endocrine organ. It actively controls the degree of vascular relaxation and constriction, and the extravasation of solutes, fluid, macromolecules and hormones, as well as that of platelets and blood cells. Through control of vascular tone, EC regulate the regional blood flow. They also direct inflammatory cells to foreign materials, areas in need of repair or defense against infections. In addition, EC are important in controlling blood fluidity, platelet adhesion and aggregation, leukocyte activation, adhesion, and transmigration. They also tightly keep the balance between coagulation and fibrinolysis and play a major role in the regulation of immune responses, inflammation and angiogenesis. To fulfill these different tasks, EC are heterogeneous and perform distinctly in the various organs and along the vascular tree. Important morphological, physiological and phenotypic differences between EC in the different parts of the arterial tree as well as between arteries and veins optimally support their specified functions in these vascular areas. This review updates the current knowledge about the morphology and function of endothelial cells, particularly their differences in different localizations around the body paying attention specifically to their different responses to physical, biochemical and environmental stimuli considering the different origins of the EC.
著者KRÜGER-GENGE A., BLOCKI A., FRANKE R., JUNG F.
期刊名稱International Journal of Molecular Sciences
出版年份2019
月份9
卷號20
期次18
出版社NLM (Medline)
文章號碼4411
國際標準期刊號1661-6596
語言英式英語
關鍵詞glycocalyx, shear stress, angiogenesis, endothelium, thrombosis

上次更新時間 2020-23-10 於 00:11