BMP/SMAD activity controls the temporal identity transition of neural progenitors in developing cerebellum
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摘要The radial glial cells lining along the ventricular zone (VZ) of developing cerebellum sequentially generates the Purkinje cells, GABAergic interneurons and astroglial cells. However, the molecular mechanisms that execute fate transition of neural progenitors from one temporal identity to another remain poorly understood. Here we show that BMP/SMAD activity is highly dynamic in the VZ during embryonic cerebellar development. The gradual reduction of SMAD1/5 activity along the dorsal/ventral axis permits Gsx1 expression, which promotes interneuron specification but suppresses Purkinje cell fate. Further analyses reveal the strength of BMP/SMAD activity directly determines the pace of temporal identity transition of GABAergic neuronal progenitors, thereby controlling the generation of Purkinje cells and interneurons. Furthermore, we found that activation of BMP/SMAD signaling is essential for Bergmann glia induction after the transition to gliogenic phase. In summary, the spatiotemporal dynamics of BMP/SMAD activity enables proper generation of various cerebellar VZ derivatives. Moreover, our findings provide novel insights into the molecular mechanism underlying the temporal identity transition of cerebellar neural progenitors.
The work described in this abstract is supported by the grants from Research Grant Council of Hong Kong Special Administration Region, China (Project No. GRF 466412 and AoE/M-05/12)
出版社接受日期12.06.2019
著者Kin Ming Kwan, Tsz Ching Ma, Keng Ioi Vong
會議名稱Society for Developmental Biology 78th Annual Meeting
會議開始日26.07.2019
會議完結日30.07.2019
會議地點Boston, MA
會議國家/地區美國
出版年份2019
語言美式英語

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