BMP/SMAD activity controls the temporal identity transition of neural progenitors in developing cerebellum
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AbstractThe radial glial cells lining along the ventricular zone (VZ) of developing cerebellum sequentially generates the Purkinje cells, GABAergic interneurons and astroglial cells. However, the molecular mechanisms that execute fate transition of neural progenitors from one temporal identity to another remain poorly understood. Here we show that BMP/SMAD activity is highly dynamic in the VZ during embryonic cerebellar development. The gradual reduction of SMAD1/5 activity along the dorsal/ventral axis permits Gsx1 expression, which promotes interneuron specification but suppresses Purkinje cell fate. Further analyses reveal the strength of BMP/SMAD activity directly determines the pace of temporal identity transition of GABAergic neuronal progenitors, thereby controlling the generation of Purkinje cells and interneurons. Furthermore, we found that activation of BMP/SMAD signaling is essential for Bergmann glia induction after the transition to gliogenic phase. In summary, the spatiotemporal dynamics of BMP/SMAD activity enables proper generation of various cerebellar VZ derivatives. Moreover, our findings provide novel insights into the molecular mechanism underlying the temporal identity transition of cerebellar neural progenitors.
The work described in this abstract is supported by the grants from Research Grant Council of Hong Kong Special Administration Region, China (Project No. GRF 466412 and AoE/M-05/12)
Acceptance Date12/06/2019
All Author(s) ListKin Ming Kwan, Tsz Ching Ma, Keng Ioi Vong
Name of ConferenceSociety for Developmental Biology 78th Annual Meeting
Start Date of Conference26/07/2019
End Date of Conference30/07/2019
Place of ConferenceBoston, MA
Country/Region of ConferenceUnited States of America
Year2019
LanguagesEnglish-United States

Last updated on 2020-19-05 at 12:11