Multiple roles of BMP/Smad signaling in controlling the fate of neural progenitor cells in mouse cerebellum
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AbstractThe neural progenitor cells in the ventricular zone of cerebellum arer esponsible for the generation of
GABAergic neurons, astrocytes and Bergmann glia. We found that the BMP/Smad signaling was
activated in the ventricula rzone throughout embryo nic development of cerebellum. After the on set of
gliogenesis, phosphorylated Smad1/5 were also expressed bySox9+ astrocytes in the prospective white
matter and the Purkinje cell layer. To identify the role of BMP signaling in regulating neural progenitor
cell behavior, we employed the Cre/loxP system to ablate Smad1/5 in mouse cerebellum. Our findings
suggest that BMP signaling plays acritical role in controlling the balance between symmetric and
asymmetric division of neural progenitor cells. Loss of Smad1/5 resulted in precocious generation of
GABAergicneurons.TheBMPsignalingalsoregulatedproliferationofneuralprogenitorcellsduring
embryonic cerebellar development. Intraventricular injection of BMP7 induced proliferation of neural
progenitor cells resided in the ventricular zone while this was reduced significantly in Smad1/5
conditional knockout mutants. Deletion of Smad1/5 impaired the generation of Sox9+ astrocytes from
the ventricular zone. We showed that BMP signaling is required for the induction of Bergmann glia and
formation of glial scaffold at cerebellar cortex. Altogether, BMP/Smad signaling determines the fate of
neural progenitor cells and modulates the neurogenesis program in cerebellum. Our findings also
suggest a novel role of Smad1/5 mediated signaling in the formation of glial scaffold in cerebellum.
All Author(s) ListT.C. Ma, K.I. Vong, K.M. Kwan
Name of Conference2018 ASCB | EMBO Meeting
Start Date of Conference08/12/2018
End Date of Conference12/12/2018
Place of ConferenceSan Diego
Country/Region of ConferenceUnited States of America
Year2018
LanguagesEnglish-United States

Last updated on 2020-03-05 at 17:40