Mesenchymal stem cells and cancer: clinical challenges and opportunities
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AbstractStem cell-based therapies exhibit profound therapeutic potential for treating various human diseases, including cancer. Among the cell types that can be used for this purpose, mesenchymal stem cells (MSCs) are considered as promising source of stem cells in personalized cell-based therapies. The inherent tumor-tropic property of MSCs can be used to target cancer cells. Although the impacts of MSCs on tumor progression remain elusive, they have been genetically modified or engineered as targeted anticancer agents which could inhibit tumor growth by blocking different processes of tumor. In addition, there are close interactions between MSCs and cancer stem cells (CSCs). MSCs can regulate the growth of CSCs through paracrine mechanisms. This review aims to focus on the current knowledge about MSCs-based tumor therapies, the opportunities and challenges, as well as the prospective of its further clinical implications.
Acceptance Date10/04/2019
All Author(s) ListWeiping Lin, Lifeng Huang, Ying Li, Bin Fang, Gang Li, Leilei Chen, Liangliang Xu
Journal nameBioMed Research International
Year2019
Month5
Day8
PublisherHindawi
Place of PublicationUSA
Article number2820853
ISSN2314-6133
eISSN2314-6141
LanguagesEnglish-United States
KeywordsMSCs

Last updated on 2020-01-04 at 00:36