A randomized controlled trial evaluating efficacy of promoting human papillomavirus (HPV) vaccination among Chinese men who have sex with men
Refereed conference paper presented and published in conference proceedings


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AbstractAim: HPV-related disease burden is high among men who have sex with men (MSM). HPV vaccination is highly effective in preventing HPV-related diseases among men but under-utilized by Chinese MSM. The primary objective of the randomized controlled trial (RCT) study is to evaluate the relative efficacies of two online, theory-based and interactive interventions [online health communication with and without motivational interviewing (MI)] in increasing uptake of three required doses of HPV vaccination within a 24-month follow-up period among Hong Kong Chinese MSM, as compared to the control group.

Methods: A three-arm parallel-group, non-blinded randomized controlled trial was conducted. Participants were Hong Kong Chinese speaking MSM who had never received HPV vaccination. A total of 624 eligible MSM will be recruited and randomized 1:1:1 into three groups: 1) Group HC (Online Health Communication Only Group): exposure to interactive and theory-based online health communication promoting HPV vaccination among MSM, 2) Group HC-MI (Online Health Communication plus MI): receiving 15-minute MI over phone, administered by a trained fieldworkers, on top of the health promotion given to Group HC, and 3) Control group: exposure to online health communication related to mental health that was unrelated to HPV vaccination. The online health communication messages were developed based on the Health Belief Model (HBM). Participants were given coded discount coupons (10% discount of the market price) for taking up the three doses of HPV vaccines at a collaborating private clinic. They could take them up at other clinics at market price. Self-reported uptake of HPV vaccination was validated by requesting participants to send photos of their receipts. Participants were followed up by telephone at Month 3, 6, 9 and 24.

Results:
Using intention-to-threat (ITT) analysis, the prevalence of completing all three required doses of HPV vaccination during the 24-month follow-up period was 14.9% in the HC-MI group (31/208), 9.1% in the HC group (19/208), and 4.3% in the control group (9/208). The completion rate was significantly higher in the HC-MI group than that of the control group (RR: 3.44, 95%CI: 1.68, 7.06, p<0.001). The differences between the HC-MI group and HC group (RR: 1.63, 95%CI: 0.95, 2.79, 0.05
All Author(s) ListWang Z, Lau JT, Ip M, Lam PKP, Fong F, Chan P
Name of ConferenceAIDSImpact 14th International Conference
Start Date of Conference29/07/2019
End Date of Conference31/07/2019
Place of ConferenceLondon
Country/Region of ConferenceGreat Britain
Year2019
Month7
Day31
LanguagesEnglish-United Kingdom

Last updated on 2020-18-05 at 12:11