Piloting a partially self-financed mode of human immunodeficiency virus pre-exposure prophylaxis delivery for men who have sex with men in Hong Kong
Publication in refereed journal


Times Cited
Altmetrics Information
.

Other information
AbstractIntroduction: Pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF) 300 mg/ emtricitabine (FTC) 200 mg is a proven strategy for preventing human immunodeficiency virus (HIV) transmission in men who have sex with men (MSM). This study aimed to test the feasibility and acceptability of PrEP delivered at a pilot clinic for MSM in Hong Kong, where PrEP service is currently unavailable. Methods: Partially self-financed PrEP was provided to HIV-negative adult MSM with high behavioural risk of HIV transmission after excluding hepatitis B infection and renal insufficiency. Participants received daily TDF/FTC for 30 weeks at 13.3% of the drug cost. Adherence and behaviours were monitored through questionnaires while creatinine and HIV/ STI (sexually transmitted infection) incidence were monitored with point-of-care and laboratory tests. Preference for continuing with PrEP was evaluated at the end of the prescription period. Results: Seventy-one PrEP-naïve MSM were included in the study, of whom 57 (80%) were retained at the end of 28 weeks. Satisfactory adherence and self-limiting adverse events were reported, while none of the participants contracted HIV. Risk compensation was observed, with an STI incidence of 3.17 per 100 person-years. At the end of the prescription period, a majority (89%) indicated interest in continuing with PrEP. Preference for PrEP was associated with age ≥28 years and peer influence (P=0.04), while stigma was a concern. Price was a deterrent to self-financed PrEP, and only half (51%) considered a monthly cost of ≤HK$500 (US$1=HK$7.8) as reasonable. Conclusions: A partially self-financed mode of PrEP delivery is feasible with good retention in MSM in Hong Kong.
All Author(s) ListLee SS, Kwan TH, Wong NS, Lee KCK, Chan DPC, Lam TTN, Lui GCY
Journal nameHong Kong Medical Journal
Year2019
Month10
Volume Number25
Issue Number5
PublisherHong Kong Academy of Medicine
Pages382 - 391
ISSN1024-2708
LanguagesEnglish-United Kingdom
KeywordsHIV, PrEP, pre-exposure prophylaxis, Hong Kong

Last updated on 2021-18-04 at 23:33