The Anti-Inflammatory Activity of IL-37b on Atopic Dermatits
Other conference paper


摘要Atopic dermatitis (AD), the most common allergic skin disease in children, is characterized
with marked epidermal hyperplasia, acanthosis with inflammatory dendritic epidermal cells
and eosinophils infiltration in dermis. AD patients can react to both non-allergic and allergic
triggers and result in significant morbidity, leading to low life quality. Regulatory IL-37b is a
fundamental inhibitor of innate immunity that exerts anti-inflammatory activity in inflammatory
diseases. The function of IL-37b on AD is still unknown. In this study, IL-37b showed significant
suppression of AD-related cytokines and chemokines production in in vitro co-culture of
human eosinophils and human dermal fibroblast HDF upon stimulation by pruritogenic
cytokine IL-31 and alarmin IL-33, while antagonizing the activation of nuclear factor kappa B
(NF-κB), phosphatidylinositol -3-kinase/protein kinase B (PI3K/Akt), extracellular signalregulated
kinases 1 and 2 (ERK1/2). In vitamin D analog MC903 induced AD-like mice model,
IL-37b was effective on alleviating skin inflammation, as shown by reduced ear swelling and
down-regulated production of AD-related inflammatory cytokines and chemokines in plasma
and ear tissue. IL-37b also ameliorated the skin lesion of AD by suppression of eosinophils,
mast cells and basophils infiltration in dermis. Therefore, the present study suggested the
therapeutic potential of IL-37b in atopic dermatitis.
著者J Zhu, KL Hon, CK Wong
會議名稱Hong Kong Immunology Forum 2018
會議地點Hong Kong

上次更新時間 2020-22-04 於 09:59