Aberrantly expressed long non-coding RNAs in air pollution-induced congenital defects
Publication in refereed journal

替代計量分析
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其它資訊
摘要Air pollution has been a serious public health issue over the past few decades particularly in developing countries. Air pollution exposure during pregnancy poses potential threat to offspring as the deleterious substances might pass through placenta to alter foetal development. A growing number of studies have demonstrated that long non-coding RNAs (lncRNAs) participate in the development of many diseases, including congenital defects. Here, we used RNA sequencing to identify differentially expressed lncRNAs in air pollution-exposed rat embryos compared with control group. Our data suggested that 554 lncRNAs (216 up-regulated and 338 down-regulated) were significantly differentially expressed in the air pollution-exposed embryos. Moreover, potential cellular functions of these deregulated lncRNAs were predicted via KEGG signal pathway/GO enrichment analyses, which suggested the possible involvements of neurological process, sensory perception of smell and the G-protein signalling pathway. Furthermore, potential functional network of deregulated lncRNAs and their correlated mRNAs in the development of congenital spinal abnormality was established. Our data suggested that lncRNAs may play a vital role in the pathophysiology of air pollution-exposed congenital spinal malformation.
著者Li Z, Ma J, Li X, Chan MTV, Wu WKK, Wu Z, Shen J
期刊名稱Journal of Cellular and Molecular Medicine
出版年份2019
月份11
卷號23
期次11
出版社Wiley
頁次7717 - 7725
國際標準期刊號1582-1838
語言英式英語

上次更新時間 2020-17-09 於 00:12