Efficacy and safety of diphenylcyclopropenone among Chinese patients with steroid resistant and extensive alopecia areata
Publication in refereed journal

替代計量分析
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其它資訊
摘要Background
Topical immunotherapy has recently been found useful in the treatment of chronic and extensive Alopecia Areata (AA).

Objective
To evaluate the efficacy and safety of diphenylcyclopropenone (DPCP) use among Chinese patients with steroid resistant and extensive AA in our institute.

Methods
The medical records of 31 Chinese patients treated with DPCP were analysed retrospectively. The efficacy, adverse effects, and relapse rate of DPCP treatment were reviewed.

Results
Thirty‐one (16 male, 15 female) Chinese patients with extensive, steroid resistant Alopecia Areata and a mean age of 28.9 years (SE 10.4) were treated. The mean age of onset was 17.8 years (SE 8.8) with an average disease duration of 11.2 years (SE 7.7). Ten patients had a history of atopy and 4 had a history of thyroid disease. Nail changes were found in 14 patients and a family history of AA was found in 2 patients. Thirteen patients (41.9%) had experienced total hair loss. Two patients abandoned the treatment due to severe side effects. Of the remaining 29 patients, 4 (13.8%), 7 (24.1%), 5 (17.2%), and 13 (44.8%) achieved >90% complete response, >50–90% partial response, >10–50% minimal response, and <10% no response hair regrowth, respectively. Adverse effects included pruritus, erythema, vesiculation, scaling, cervical lymphadenopathy, dyspigmentation and urticarial reactions. Relapse occurred (>25% hair loss) in 69.23% of patients after 18 months of follow up.

Conclusions
DPCP is an effective and tolerable treatment for Chinese patients with extensive, steroid resistant AA.
著者Luk NM, Chiu LS, Lee KC, Chau CTS, Lee VWY, Chang M, Lam YK, Lee HC
期刊名稱Journal of the European Academy of Dermatology and Venereology
出版年份2013
月份3
卷號27
期次3
出版社WILEY-BLACKWELL
頁次e400 - e405
國際標準期刊號0926-9959
語言英式英語
Web of Science 學科類別Dermatology;Dermatology

上次更新時間 2021-10-05 於 01:12