Updated classification of norovirus genogroups and genotypes
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AbstractNoroviruses are genetically diverse RNA viruses associated with acute gastroenteritis in mammalian hosts. Phylogenetically, they can be segregated into different genogroups as well as P (polymerase)-groups and further into genotypes and P-types based on amino acid diversity of the complete VP1 gene and nucleotide diversity of the RNA-dependent RNA polymerase (RdRp) region of ORF1, respectively. In recent years, several new noroviruses have been reported that warrant an update of the existing classification scheme. Using previously described 2x standard deviation (SD) criteria to group sequences into separate clusters, we expanded the number of genogroups to 10 (GI-GX) and the number of genotypes to 49 (9 GI, 27 GII, 3 GIII, 2 GIV, 2 GV, 2 GVI and 1 genotype each for GVII, GVIII, GIX [formerly GII. 15] and GX). Viruses for which currently only one sequence is available in public databases were classified into tentative new genogroups (GNA1 and GNA2) and genotypes (GII. NA1, GII. NA2 and GIV. NA1) with their definitive assignment awaiting additional related sequences. Based on nucleotide diversity in the RdRp region, noroviruses can be divided into 60 P-types (14 GI, 37 GII, 2 GIII, 1 GIV, 2 GV, 2 GVI, 1 GVII and 1 GX), 2 tentative P-groups and 14 tentative P-types. Future classification and nomenclature updates will be based on complete genome sequences and will be coordinated and disseminated by the international norovirus classification-working group.
All Author(s) ListPreeti Chhabra, Miranda de Graaf, Gabriel I. Parra, Martin Chi-Wai Chan, Kim Green, Vito Martella, Qiuhong Wang, Peter A. White, Kazuhiko Katayama, Harry Vennema, Marion P. G. Koopmans, Jan Vinjé
Journal nameJournal of General Virology
Volume Number100
Issue Number10
PublisherMicrobiology Society
Pages1393 - 1406
LanguagesEnglish-United Kingdom
KeywordsNorovirus, acute gastroenteritis, classification, 2xSD criteria, genogroup, genotype, P-group, P-type

Last updated on 2021-17-09 at 00:11