Professor Kwok Wai LO - CUHK Research Portal - CONVERIS Research Information System

Go to Header Go to Navigation Go to Content Go to Footer

Professor LO Kwok Wai

Personal Information

Position and Department

Professor, Department of Anatomical and Cellular Pathology

ORCiD0000-0002-3488-6124

CUHK Research Outputs

Go to first page

Go to previous page

1 of 7

Go to next page

Go to last page

Accurate identification of structural variations from cancer samples (2024)

Synthetic BZLF1-targeted transcriptional activator for efficient lytic induction therapy against EBV-associated epithelial cancers (2024)

An Update of G-Protein-Coupled Receptor Signaling and Its Deregulation in Gastric Carcinogenesis (2023)

Cancer-associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2–IGF1R and Hippo–YAP1 signaling pathways (2023)

Frequency of Peripheral CD8+ T Cells Expressing Chemo-Attractant Receptors CCR1, 4 and 5 Increases in NPC Patients with EBV Clearance upon Radiotherapy (2023)

Human Herpesviruses: Nasopharyngeal Carcinoma and Other Epithelial Tumors (2023)

Latent membrane protein 1 and macrophage-derived TNFα synergistically activate and mobilize invadopodia to drive invasion of nasopharyngeal carcinoma (2023)

MLK4 promotes glucose metabolism in lung adenocarcinoma through CREB-mediated activation of phosphoenolpyruvate carboxykinase and is regulated by KLF5 (2023)

NEOSPACE trial: Neoadjuvant pembrolizumab-gemcitabine-cisplatin followed by concurrent pembrolizumab-chemoradiation and maintenance pembrolizumab for stage IVA nasopharyngeal cancer (NPC) (2023)

Preclinical evaluation of the VEGF/Ang2 bispecific nanobody BI 836880 in nasopharyngeal carcinoma models (2023)

Targeting YAP1/TAZ in nonsmall-cell lung carcinoma: From molecular mechanisms to precision medicine (2023)

The E2F1–HOXB9/PBX2–CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer (2023)

The molecular classification of cancer-associated fibroblasts on a pan-cancer single-cell transcriptional atlas (2023)

Therapeutic vulnerability of MTAP-deleted nasopharyngeal carcinoma by MAT2A inhibitors (2023)

Transcriptomics of Epstein-Barr virus aids to the classification of T-cell evasion in nasopharyngeal carcinoma (2023)

Accurate reconstruction of viral genomes in human cells from short reads using iterative refinement (2022)

A study on the cell composition and single-cell transcriptome of EBV-positive and EBV-negative NPC tumors grown in humanized mice (2022)

BCL3 as a unique therapeutic target for Epstein-Barr virus-associated nasopharyngeal carcinoma (2022)

Cancer-associated fibroblasts in nonsmall cell lung cancer: From molecular mechanisms to clinical implications (2022)

Characterization of DNA methylation pattern of EBV-encoded and host genes in EBV associated nasopharyngeal carcinoma (2022)

Development of aptamer-based therapeutics for treatment of EBV-associated nasopharyngeal carcinoma (2022)

Dual inhibition of anti-apoptotic proteins BCL-XL and MCL-1 enhances cytotoxicity of Nasopharyngeal carcinoma cells (2022)

Isolation of exosome from the culture medium of Nasopharyngeal cancer (NPC) C666-1 cells using inertial based Microfluidic channel (2022)

MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target (2022)

Targeting MTAP-deleted Nasopharyngeal Carcinoma by MAT2A inhibitor (2022)

The CBP/β-Catenin Antagonist, ICG-001, Inhibits Tumor Metastasis via Blocking of the miR-134/ITGB1 Axis-Mediated Cell Adhesion in Nasopharyngeal Carcinoma (2022)

A three-dimensional spheroid-specific role for Wnt–β-catenin and Eph–ephrin signaling in nasopharyngeal carcinoma cells (2021)

Combinations of indole based alkaloids from Mitragyna speciosa (Kratom) and cisplatin inhibit cell proliferation and migration of nasopharyngeal carcinoma cell lines (2021)

Dual-Targeting Peptide-Guided Approach for Precision Delivery and Cancer Monitoring by Using a Safe Upconversion Nanoplatform (2021)

Identification and Characterization of a Novel Epstein-Barr Virus-Encoded Circular RNA from LMP-2 Gene (2021)

Nasopharyngeal Carcinoma: An Evolving Paradigm (2021)

NOTCH3, a crucial target of miR-491-5p/miR-875-5p, promotes gastric carcinogenesis by upregulating PHLDB2 expression and activating Akt pathway (2021)

NPC patients with post-RT EBV clearance show a higher frequency of peripheral CD8 T-cells expressing chemo-attractant receptors at baseline and during radiation therapy (2021)

Preclinical evaluation of VEGF Ang2 bispecific nanobody BI836880 in patient-derived xenograft models of nasopharyngeal carcinoma (2021)

Quantifying full-length circular RNAs in cancer (2021)

Short-Form Thymic Stromal Lymphopoietin (sfTSLP) Is the Predominant Isoform Expressed by Gynaecologic Cancers and Promotes Tumour Growth (2021)

Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy (2021)

SSTR2 in Nasopharyngeal Carcinoma: Relationship with Latent EBV Infection and Potential as a Therapeutic Target (2021)

STK3 promotes gastric carcinogenesis by activating Ras-MAPK mediated cell cycle progression and serves as an independent prognostic biomarker (2021)

Translational genomics of nasopharyngeal carcinoma (2021)

Vulnerability of MTAP-deleted nasopharyngeal carcinoma to MAT2A inhibition (2021)

Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape (2021)

AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis (2020)

Contaminated and misidentified cell lines commonly use in cancer research (2020)

Distinct Molecular Landscape of Epstein-Barr Virus Associated Pulmonary Lymphoepithelioma-Like Carcinoma Revealed by Genomic Sequencing (2020)

EBV-encoded miRNAs can sensitize nasopharyngeal carcinoma to chemotherapeutic drugs by targeting BRCA1 (2020)

ERAP2 overexpression is a marker for reduced anti-PD-1 response in nasopharyngeal carcinoma. (2020)

Erlotinib sensitivity of MAPK1p.D321N mutation in head and neck squamous cell carcinoma (2020)

FGF18-FGFR2 signaling triggers the activation of c-Jun-YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential (2020)

MAPK1 p.D321N mutation confers sensitive to erlotinib in head and neck squamous cell carcinoma (HNSCC) (2020)

Research Interest

• NPC genomics: systematic characterization of NPC genome via next generation sequencing and informatics analysis; elucidation of genetic and epigenetic changes in NPC.
• Functional investigation of novel tumor suppressor genes and oncogenes and elucidation of critical molecular targets and oncogenic pathways in NPC.
• Epstein-Barr virus (EBV) and human cancers: investigation of the viral-host interaction of the EBV in NPC; identification of the novel cellular genes and pathways modulated by EBV latent proteins; characterization of novel EBV noncoding RNAs in NPC.
• Establishment of EBV-positive NPC models: patient-derived xenografts, cell lines and organoids.
• Development of novel biomarkers and innovative therapeutic strategies for NPC.

Most Relevant Area

Clinical and molecular pathology, and pathobiology (Laboratory medicine and technology)

Related Area

Human genetics and genomics (Experimental medicine)

Translational medicine (Experimental medicine)