Professor Eugene PONOMAREV

CUHK Research Outputs
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Research Interest
Prof. PONOMAREV Eugene (龐佑信) is currently appointed to the School of Biomedical Sciences, the Chinese University of Hong Kong, and his research interest is related to the immunological aspects of inflammation in the central nervous system (CNS) associated with neurodegenerative disease such as multiple sclerosis and Alzheimer’s disease. Particularly he is interested in 1) epigenetic and transcriptional control of microglia/macrophage activation and polarization during CNS inflammation and 2) the role of platelets in the initiation of neuroinflammation. Both directions of his research program are currently supported by RGC and HMRF grants. Dr. Ponomarev is well known scientist in field of neuroinflammation and neurodegeneration and he is an author of more than 30 publications in top academic journals such as Nature Medicine, Journal of Immunology and Journal of Neuroscience, Circulation Research. Dr. Ponomarev serves in the editorial boards of number of International academic journals such as Journal of Immunology, Journal of Neuroscience, Journal of Clinical Immunology, Annals of Neurology, Journal of Neuroinflammation, PLOS ONE etc. Before his relocation to Hong Kong, Eugene Ponomarev spent 12 years in the USA working as a scientist in top academic institutions such as Brigham and Women’s Hospital, Harvard Medical School (Boston MA) where he held the position of Assistant Professor and his work was supported by RO1 grant form National Institute of Health.

Five recent representative publications:
1. Starossom S.C., Veremeyko T, Dukhinova M., Yung A.W.Y., Weiner H.L., Ponomarev E.D Platelets Play Differential Role in the Regulation of the Initiation and Progression of Autoimmune Neuroinflammation. Circulation Research. 2015. 117 (9): 779-792
2. Starossom S.C., Veremeyko T, Dukhinova M., Yung A.W.Y., Ponomarev E.D. Glatiramer acetate (Copaxone) modulates platelet activation and inhibits thrombin-induced calcium influx: possible role of Copaxone in targeting platelets during autoimmune neuroinflammation. PLOS ONE. 2014. 9(5): e96256.
3. Veremeyko T., Siddiqui S., Sotnikov I., Yung A and Ponomarev E.D. IL-4/IL-13-Dependent and Independent Expression of miR-124 and its Contribution to M2 Phenotype of Monocytic Cells in Normal Conditions and During Allergic Inflammation. PLOS ONE. 2013. 8(12): e81774.
4. Sotnikov I., Vermeyko T., Starossom S.C., Barteneva N., Weiner H.L. and Ponomarev E.D. Platelets recognize brain-specific glycolipid structures, respond to neurovascular damage and promote neuroinflammation. PLOS ONE. 2013. 8(3): e58979.
5. Ponomarev E.D., Veremeyko T., Krichevsky A.K. and Weiner H.L. MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the CEBPalpha-PU.1 pathway. Nat. Med. 2011, 17:64-70

Technical expertise:
Immune cell isolation from different organs and their identification
Cell cultures: neuronal and immune cells
Experimental Autoimmune Encephalitis (EAE)
FACS analysis (cell subsets, intracellular staining)
microRNA
Platelets / Glycolipids

Last updated on 2020-14-06 at 06:40